Presented here are the results of a study that evaluated the analytical precision for natural uranium sample (assumed 235U/238U = 0.0072) determinations. These efforts build off previous work in this coupling, where the more » importance of a few of the LS-APGD discharge parameters and Orbitrap data acquisition methods on IR precision and accuracy were probed. While the Orbitrap platform has demonstrated excellent mass resolution and accuracy in “organic” mass spectrometry (MS) applications, work using an Orbitrap for IR analysis is very sparse. Based on past experience with the Thermo Exactive Orbitrap mass analyzer, the LS-APGD was interfaced with this instrument for these tests. To this end, characterization of the capabilities in performing precise and accurate isotope ratio (IR) determinations is essential. For the injection of a 100 μL aliquot, the % RSD was reduced from 5.3% to = ,Ībstract The continued development of the liquid sampling-atmospheric pressure glow discharge (LS-APGD) microplasma as an ion source for diverse, elemental/isotopic analysis applications continues.
For example, employing a 40-point window width in the moving average to direct infusion data reduced the percent relative standard deviation (% RSD) of the 235U/238U values from 3.4% to 0.5%. These reductions have allowed isotope ratio (IR) determinations to be made using injections instead of direct infusion of the analyte. Additionally, use of the moving average minimizes the quantity of sample that needs to be analyzed while reducing the measurement time.
HEXELS 2 GLOW WINDOWS
Additionally, the use of a moving average (of data windows of various widths) improves the precision of the ratio measurements and reduces the number of scans needed to be collected to generate high-precision results. While the LS-APGD has been proven capable of determining the 235U/238U isotope ratio in enriched and natural uranium, recent efforts have strived to reduce the analysis time of individual measurements by employing higher-order data processing techniques, specifically, moving average methods.
The liquid sampling-atmospheric pressure glow discharge (LS-APGD) is a versatile combined atomic and molecular (CAM) ionization source capable of ionizing elemental species, small polar compounds, low-polarity polycyclic aromatic hydrocarbons, and proteins.
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